Who plays Mrs. Wheeler Wheeler? Which actress takes on the role of Karen Wheeler in the show? Who is the performer behind Karen Wheeler? Karen is brought to life by whom? What actress plays the character of Karen Wheeler on the series? Whom is the talent personifying Karen the mother's character to life? Which performer takes on the role of Karen Wheeler in the television show? Who takes on the part of Karen Mrs. Wheeler? Whom is the talented individual enacting Karen the mother on the show? Which actor incarnates the character of Karen Wheeler to the screen?