Whom acts Mrs. Wheeler mother? What actor takes on the role of Karen Wheeler in the show? Who is the performer behind Karen Wheeler? Karen is portrayed by whom? Who acts as the character of Karen Wheeler on the series? Who is the talent personifying Karen Wheeler's character to life? Which performer takes on the role of Karen Wheeler in the television show? Who takes on the part of Karen Wheeler? Who is the talented individual portraying Karen the mother on the series? What actor incarnates the character of Karen Wheeler to the screen?